Allergy Research in Vancouver, WA
Types of Allergy
What Is an Allergy?
An allergy is a specific reaction of the body’s immune system to a normally harmless substance, one that does not bother most people. People who have allergies often are sensitive to more than one substance. Types of allergens that cause allergic reactions include:
- House Dust Mites
- Mold Spores
- Latex Rubber
- Insect Venom
Why Are Some People Allergic?
Scientists think that some people inherit a tendency to be allergic from one or both parents. This means they are more likely to have allergies. They probably, however, do not inherit a tendency to be allergic to any specific allergen. Children are more likely to develop allergies if one or both parents have allergies. In addition, exposure to allergens at times when the body’s defenses are lowered or weakened, such as after a viral infection or during pregnancy, seems to contribute to developing allergies.
What Is an Allergic Reaction?
Normally, the immune system functions as the body’s defense against invading germs such as bacteria and viruses. In most allergic reactions, however, the immune system is responding to a false alarm. When an allergic person first comes into contact with an allergen, the immune system treats the allergen as an invader and gets ready to attack.
The immune system does this by generating large amounts of a type of antibody called immunoglobulin E, or IgE. Each IgE antibody is specific for one particular substance. In the case of pollen allergy, each antibody is specific for one type of pollen. For example, the immune system may produce one type of antibody to react against oak pollen and another against ragweed pollen.
The IgE molecules are special because IgE is the only type of antibody that attaches tightly to the body’s mast cells, which are tissue cells, and to basophils, which are blood cells. When the allergen next encounters its specific IgE, it attaches to the antibody like a key fitting into a lock. This action signals the cell to which the IgE is attached to release (and, in some cases, to produce) powerful chemicals like histamine, which cause inflammation. These chemicals act on tissues in various parts of the body, such as the respiratory system, and cause the symptoms of allergy.
The signs and symptoms of airborne allergies are familiar to many:
- Sneezing, Often with a Runny or Clogged Nose
- Coughing and Postnasal Drip
- Itching Eyes, Nose, and Throat
- Watering Eyes
- “Allergic Shiners” (dark circles under the eyes caused by increased blood flow near the sinuses)
- “Allergic Salute” (in a child, persistent upward rubbing of the nose that causes a crease mark on the nose)
In people who are not allergic, the mucus in the nasal passages simply moves foreign particles to the throat, where they are swallowed or coughed out. But something different happens in a person who is sensitive to airborne allergens.
In sensitive people, as soon as the allergen lands on the lining inside the nose, a chain reaction occurs that leads the mast cells in these tissues to release histamine and other chemicals. The powerful chemicals contract certain cells that line some small blood vessels in the nose. This allows fluids to escape, which causes the nasal passages to swell–resulting in nasal congestion. Histamine also can cause sneezing, itching, irritation, and excess mucus production, which can result in allergic rhinitis.
Other chemicals released by mast cells, including cytokines and leukotrienes, also contribute to allergic symptoms.
Some people with allergy develop asthma, which can be a very serious condition. The symptoms of asthma include:
- Shortness of Breath
The shortness of breath is due to a narrowing of the airways in the lungs and to excess mucus production and inflammation. Asthma can be disabling and sometimes fatal. When wheezing and shortness of breath follow allergy symptoms, it’s a warning that airways are involved.
Is It a Common Cold or Is It Allergies?
There’s no good way to know the difference between allergies and colds when the symptoms are sneezing and runny nose, other than that allergy symptoms tend to last longer. Anyone who suffers a respiratory illness longer than a week or two should consult a healthcare provider.
The Pains of a Pollen Allergy
In every season except winter, tiny pollen grains are released from trees, weeds, and grasses. These grains hitch rides on air currents. Although the purpose of pollen is to fertilize parts of other plants, many never reach their targets. Instead, it infiltrates human noses and throats, triggering seasonal allergic rhinitis that many know as hay fever.
Of all the allergy causes, pollen is one of the most prominent and difficult to stop. Most triggering foods, medicines, or animals can be avoided to a great extent, and even insects and household dust are escapable. But short of staying indoors with the windows closed when the pollen count is high—and even that doesn’t always help—there is no easy way to avoid airborne pollen.
The Details of Pollen
Plants produce round or oval pollen grains to reproduce that are so small they can’t be seen with the naked eye. Some plants use the pollen from their own flowers to fertilize themselves while others types need to cross-pollinate. The latter means that for fertilization to happen and produce seeds, pollen needs to move from one plant’s flower to another of the same species. Some plants rely on insects for this job while others depend on the wind.
The pollen that most commonly triggers reactions is produced by plain-looking plants without obvious flowers. They make small, light, dry grains custom-made for wind transport.
Scientists have collected samples as far as 400 miles at sea and 2 miles high in the air. Because airborne pollen can drift for many miles, it does little good to rid an area of an offending plant. In addition, most allergenic pollen comes from plants that produce it in huge quantities. For example, a single ragweed plant can generate a million grains of pollen a day.
The type of allergens in the pollen is the main factor that determines whether the pollen is likely to cause hay fever. For example, pine tree pollen is produced in large amounts by a common tree, which would make it a good candidate for causing allergy. It is, however, a relatively rare cause of allergy because the types of allergens in pine pollen appear to make it less allergenic.
Among North American plants, weeds are the most prolific producers of allergenic pollen. Ragweed is the major culprit, but other important sources are sagebrush, redroot pigweed, lamb’s quarters, Russian thistle (tumbleweed), and English plantain.
Grasses and trees, too, are important sources of allergenic pollens. Although more than 1,000 species of grass grow in North America, only a few produce highly allergenic pollen.
People falsely say they’re allergic to flowers like roses that are scented and colorful. In truth, only people with long-term close contact with flowers, such as florists and gardeners, are likely to have this problem. Most of us have little contact with these large, heavy, waxy pollen grains because they’re carried by bees and butterflies.
Some pollen-producing grasses include:
- Timothy Grass
- Kentucky Bluegrass
- Johnson Grass
- Bermuda Grass
- Redtop Grass
- Orchard Grass
- Sweet Vernal Grass
Some pollen-producing trees include:
- Mountain Cedar
When Do Plants Produce Their Pollen?
One of the most obvious features of an allergy like this is the seasonal nature—symptoms appear only when the grains people are allergic to are in the air. Every plant has more or less the same pollinating period each year. Exactly when a plant starts pollinating depends on the length of day and night—and therefore on geography—rather than on the weather. On the other hand, weather conditions during pollination can affect the amount of pollen produced and distributed in a specific year. Thus, in the Northern Hemisphere, the farther north you go, the later the start of the pollinating period and the later the start of the allergy season.
A pollen count, familiar to many people from local weather reports, is a measure of how much pollen is in the air. This count represents the concentration of all of the pollen (or of one particular type, like ragweed) in the air in a certain area at a specific time. It is shown in grains of pollen per square meter of air collected over 24 hours. Pollen counts tend to be the highest early in the morning on warm, dry, breezy days and lowest during chilly, wet periods. Although the pollen count is an approximate measure that changes, it is useful as a general guide for when it may be wise to stay indoors and avoid contact with the pollen.
What Is Mold?
There are thousands of types of molds and yeasts in the fungus family. Yeasts are single cells that divide to form clusters. Molds are made of many cells that grow as branching threads called hyphae. Although both can probably cause allergic reactions, only a small number of molds are widely recognized offenders.
The seeds or reproductive pieces of fungi are called spores. Spores differ in size, shape, and color among types of mold. Each spore that germinates can give rise to new mold growth, which in turn can produce millions of spores.
What Is Mold Allergy?
When inhaled, tiny fungal spores, or sometimes pieces of fungi, may cause allergic rhinitis. Because they are so small, mold spores also can reach the lungs. In a small number of people, symptoms of mold allergy may be brought on or worsened by eating certain foods such as cheeses processed with fungi. Occasionally, mushrooms, dried fruits, and foods containing yeast, soy sauce, or vinegar will produce allergy symptoms.
Where Do Molds Grow?
Molds can be found wherever there is moisture, oxygen, and a source of the few other chemicals they need. In the fall, they grow on rotting logs and fallen leaves, especially in moist, shady areas. In gardens, they can be found in compost piles and on certain grasses and weeds. Some molds attach to grains such as wheat, oats, barley, and corn, which makes farms, grain bins, and silos likely places to find mold.
Hot spots of mold growth in the home include:
- Damp Basements and Closets
- Bathrooms (especially shower stalls)
- Places Where Fresh Food is Stored
- Refrigerator Drip Trays
- House Plants
- Air Conditioners
- Garbage Pails
- Upholstered Furniture
- Old Foam Rubber Pillows
Molds also like bakeries, breweries, barns, dairies, and greenhouses. Loggers, mill workers, carpenters, furniture repairers, and upholsterers often work in moldy environments.
What Molds Are Allergenic?
Like pollens, mold spores are important airborne allergens only if they are abundant, easily carried by air currents, and allergenic in their chemical makeup. Found almost everywhere, mold spores in some areas are so numerous they often outnumber the pollens in the air. Fortunately, however, only a few dozen different types are significant allergens.
In general, Alternaria and Cladosporium (Hormodendrum) are the molds most commonly found both indoors and outdoors in the United States. Aspergillus, Penicillium, Helminthosporium, Epicoccum, Fusarium, Mucor, Rhizopus, and Aureobasidium (Pullularia) are common as well.
There is no relationship, however, between a respiratory allergy to the mold Penicillium and an allergy to the drug penicillin, which is made from mold.
Are Mold Counts Helpful?
Similar to pollen counts, mold counts may suggest the types and number of fungi present at a certain time and place. For several reasons, however, these counts probably cannot be used as a constant guide for daily activities.
One reason is that the number and types of spores actually present in the mold count may have changed considerably in 24 hours because weather and spore distribution are directly related. Many common allergenic molds are of the dry spore type—they release their spores during dry, windy weather. Other fungi need high humidity, fog, or dew to release their spores. Although rain washes many larger spores out of the air, it also causes some smaller spores to be propelled into the air.
In addition to the effect of weather changes during 24-hour periods on mold counts, spore populations may also differ between day and night. Dry spore types are usually released during daytime, and wet spore types are usually released at night.
Are There Other Mold-Related Disorders?
Fungi or organisms related to them may cause other health problems similar to allergic diseases. Some kinds of Aspergillus may cause several different illnesses, including both infections and allergies. These fungi may lodge in the airways or a distant part of the lung and grow until they form a compact sphere known as a “fungus ball.” In people with lung damage or serious underlying illnesses, Aspergillus may grasp the opportunity to invade the lungs or the whole body.
In some people, exposure to these fungi also can lead to asthma or to a lung disease resembling severe inflammatory asthma called allergic bronchopulmonary aspergillosis. This latter condition, which occurs only in a small number of people with asthma, causes wheezing, low-grade fever, and coughing up of brown-flecked masses or mucus plugs. Skin testing, blood tests, X-Rays, and examination of the sputum for fungi can help establish the diagnosis. Corticosteroid drugs usually treat this reaction effectively. Immunotherapy (allergy shots) is not helpful.
Dust Mite Allergy
Dust mite allergy is an allergy to a microscopic organism that lives in the dust found in all dwellings and workplaces. House dust, as well as some house furnishings, contains microscopic mites. Dust mites are perhaps the most common cause of perennial allergic rhinitis. House dust mite allergy usually produces symptoms similar to pollen allergy and also can produce symptoms of asthma.
House dust mites, which live in bedding, upholstered furniture, and carpets, thrive in summer and die in winter. In a warm, humid house, however, they continue to thrive even in the coldest months. The particles seen floating in a shaft of sunlight include dead dust mites and their waste products. These waste products, which are proteins, actually provoke the allergic reaction.
What Is House Dust?
Rather than a single substance, so-called house dust is a varied mixture of potentially allergenic materials. It may contain fibers from different types of fabrics and materials such as:
- Cotton Lint, Feathers, and Other Stuffing Materials
- Dander from Cats, Dogs, and Other Animals
- Mold and Fungus Spores (especially in damp areas)
- Food Particles
- Bits of Plants and Insects
- Other Allergens Peculiar to an Individual House or Building
Cockroaches are commonly found in crowded cities and in the southern United States. Certain proteins in cockroach feces and saliva also can be found in house dust. These proteins can cause allergic reactions or trigger asthma symptoms in some people, especially children. Cockroach allergens likely play a significant role in causing asthma in many inner-city populations.
Household pets are the most common source of allergic reactions to animals. Many people think that pet allergy is provoked by the fur of cats and dogs. Researchers have found, however, that the major allergens are proteins in the saliva. These proteins stick to the fur when the animal licks itself.
Urine is also a source of allergy-causing proteins, as is the skin. When the substance carrying the proteins dries, the proteins can then float into the air. Cats may be more likely than dogs to cause allergic reactions because they lick themselves more, may be held more, and spend more time in the house, close to humans.
Some rodents, such as guinea pigs and gerbils, have become increasingly popular as household pets. They, too, can cause allergic reactions in some people, as can mice and rats. Urine is the major source of allergens from these animals.
Allergies to animals can take two years or more to develop and may not decrease until six months or more after ending contact with the animal. Carpet and furniture are a reservoir for pet allergens, and the allergens can remain in them for four to six weeks. In addition, these allergens can stay in household air for months after the animal has been removed. Therefore, it is wise for people with an animal allergy to check with the landlord or previous owner to find out if furry pets lived on the premises.
Some people report that they react to chemicals in their environments and that these allergy-like reactions seem to result from exposure to a wide variety of synthetic and natural substances. Such substances can include those found in:
- Cigarette Smoke
Although the symptoms may resemble those of allergies, sensitivity to chemicals does not represent a true allergic reaction involving IgE and the release of histamine or other chemicals. Rather than a reaction to an allergen, it is a reaction to a chemical irritant, which may affect people with allergies more than others.
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